Prognostic value of uterine natural killer (uNK) cells density in peri-implantation endometrium from women with recurrent implantation failure
نویسندگان
چکیده
منابع مشابه
Standardisation of uterine natural killer (uNK) cell measurements in the endometrium of women with recurrent reproductive failure.
Considerable work is being carried out on endometrial NK cells to determine whether they play a role in successful pregnancy outcome. In addition there is debate about whether measurements of uNK should be included in the clinical assessment for women with recurrent implantation failure or recurrent miscarriage. A hindrance to taking this forward is the fact that the density of uNK cells report...
متن کاملPrognostic value of the measurement of uterine natural killer cells in the endometrium of women with recurrent miscarriage.
BACKGROUND Studies in mice suggest that CD56 + uterine natural killer (uNK) cells play an important role in implantation. Studies in humans have described an increase in the number of uNK cells in the non-pregnant mid-secretory endometrium of women with unexplained recurrent miscarriage (RM). However, the predictive value of uNK cell number in the maintenance of pregnancy is controversial. ME...
متن کاملO-167 Standardisation of uterine natural killer (uNK) cell measurements in endometrium of women with recurrent miscarriage
Study question: Can assessment of density of uterine natural killer (uNK) cells be standardised across different research laboratories? Summary answer: Analysis of the same fifteen sections in three different centres showed variation which could be attributed to tissue processing, image capture, where in the tissue sample assessment images were taken and what was counted as an immunopositive ce...
متن کاملCytokine Profile in the Endometrium of Normal Fertile and Women with Repeated Implantation Failure
Background: Repeated Implantation Failure (RIF) is one of the most intricate obstacles in assisted reproduction. The cytokine and chemokine composition of uterine cavity seem to play important roles in the implantation process. Objective: To compare the cytokine profile in the endometrium of normal fertile women and those with repeated implantation failure. Methods: After enzymatic digestion of...
متن کاملI-24: Recurrent Implantation Failure
Recurrent implantation failure (RIF) has many definitions, but usually authors consider RIF, the failure to achieve a pregnancy fallowing 2-6 IVF cycles in which more than 10 high grade embryos were transferred to the uterus. There are a lot of causes for RIF but two main causes of that are related to embryo and endometrium. Chromosomal abnormalities, zona hardening and problems in culture medi...
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ژورنال
عنوان ژورنال: Fertility and Sterility
سال: 2019
ISSN: 0015-0282
DOI: 10.1016/j.fertnstert.2019.07.1350